Understanding Austedo XR Side Effects: 6 Key Points

Learn about common, serious, and important considerations regarding Austedo XR side effects. Understand when to consult your healthcare provider.

Understanding Austedo XR Side Effects: 6 Key Points


Austedo XR (deutetrabenazine extended-release) is a prescription medication used to treat tardive dyskinesia and chorea associated with Huntington's disease. Like all medications, Austedo XR can cause side effects. Understanding these potential effects is an important part of your treatment journey. This article provides general information about Austedo XR side effects for educational purposes and is not a substitute for professional medical advice. Always consult with your healthcare provider for personalized guidance regarding your medication and health.

1. What Austedo XR Is and How It Works (Briefly)


Austedo XR belongs to a class of medications called VMAT2 (vesicular monoamine transporter 2) inhibitors. It works by decreasing the amount of certain chemicals in the brain, which can help to reduce uncontrolled movements associated with tardive dyskinesia and Huntington's disease chorea. Its extended-release formulation allows for once-daily dosing.

2. Common Side Effects to Be Aware Of


Many individuals taking Austedo XR experience mild to moderate side effects. These are often manageable and may decrease as your body adjusts to the medication. Common side effects reported include:



  • Somnolence (drowsiness) or sedation

  • Diarrhea or constipation

  • Dry mouth

  • Insomnia or other sleep disturbances

  • Fatigue

  • Nausea

  • Anxiety


If these side effects are persistent, worsen, or become bothersome, it's important to discuss them with your healthcare provider. They may be able to suggest strategies to manage them or adjust your dosage.

3. Serious Side Effects Requiring Immediate Attention


While less common, some side effects of Austedo XR can be serious and require immediate medical attention. It is crucial to be aware of these and to seek help promptly if they occur:



  • Depression and Suicidality: Austedo XR carries a Boxed Warning regarding the risk of depression and suicidal thoughts or behavior, particularly in patients with Huntington's disease. Monitor for new or worsening depression, mood changes, anxiety, agitation, panic attacks, or thoughts of self-harm.

  • Neuroleptic Malignant Syndrome (NMS): A rare but severe reaction that can occur with medications affecting dopamine levels. Symptoms may include high fever, muscle rigidity, confusion, sweating, and irregular pulse or blood pressure.

  • QT Prolongation: Austedo XR can affect the heart's electrical activity, potentially leading to an irregular heartbeat. Symptoms might include dizziness, fainting, or palpitations.

  • Parkinsonism: Worsening of Parkinson-like symptoms (tremor, stiffness, difficulty moving) can occur or emerge.

  • Akathisia: A feeling of restlessness and an inability to sit still.

  • Swallowing Difficulty (Dysphagia): This can potentially lead to aspiration pneumonia.


If you experience any of these severe symptoms, contact your doctor or emergency services immediately.

4. Managing and Monitoring Side Effects


Proactive management and regular monitoring can help address potential side effects. Your healthcare provider will likely schedule follow-up appointments to assess your response to treatment and check for any adverse effects. You can contribute by:



  • Keeping a detailed log of any new symptoms or changes you experience.

  • Being open and honest with your doctor about all side effects, no matter how minor they seem.

  • Not adjusting your dosage or stopping the medication without your doctor's guidance.

  • Attending all scheduled medical appointments.


Never hesitate to report new or worsening symptoms, especially concerning mood or movement changes.

5. Important Precautions and Drug Interactions


Before starting Austedo XR, inform your doctor about all your medical conditions, especially if you have heart problems, mental health conditions, liver impairment, or are pregnant or breastfeeding. It's also vital to disclose all medications you are currently taking, including prescription drugs, over-the-counter medications, herbal supplements, and vitamins. Austedo XR can interact with various substances, including other medications that affect heart rhythm (like certain antipsychotics or antiarrhythmics) or drugs that cause drowsiness. Alcohol consumption can also exacerbate drowsiness.

6. When to Consult Your Healthcare Provider


Your healthcare provider is your primary resource for managing your treatment. It is essential to consult them:



  • Before starting any new medication or supplement while taking Austedo XR.

  • If you experience any new, worsening, or bothersome side effects.

  • If you have concerns about your mood, behavior, or thoughts of self-harm.

  • If you develop symptoms of an allergic reaction (e.g., rash, itching, swelling, severe dizziness, trouble breathing).

  • If your underlying condition (tardive dyskinesia or Huntington's chorea) seems to worsen or change significantly.


Always seek professional medical advice for diagnosis and treatment.

Summary


Austedo XR is an effective medication for certain movement disorders, but understanding its potential side effects is key to safe use. While common side effects like drowsiness or digestive issues are often manageable, it's crucial to be aware of and monitor for serious risks such as depression, suicidal thoughts, NMS, or heart rhythm changes. Open communication with your healthcare provider about all symptoms and concerns, along with adherence to their guidance, ensures the safest and most effective treatment experience. This information is for educational purposes only and does not substitute for professional medical advice from a qualified healthcare provider.